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Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide

Tumor-targeted drug delivery systems offer not only the advantage of an enhanced therapeutic index, but also the possibility of overcoming the limitations that have largely restricted drug design to small, hydrophobic, “drug-like” molecules. Here, we explore the ability of a tumor-targeted delivery...

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Publicado en:Mol Pharm
Autores principales: Svoronos, Alexander A., Bahal, Raman, Pereira, Mohan C., Barrera, Francisco N., Deacon, John C., Bosenberg, Marcus, DiMaio, Daniel, Glazer, Peter M., Engelman, Donald M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191262/
https://ncbi.nlm.nih.gov/pubmed/31855437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00883
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