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Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide

Tumor-targeted drug delivery systems offer not only the advantage of an enhanced therapeutic index, but also the possibility of overcoming the limitations that have largely restricted drug design to small, hydrophobic, “drug-like” molecules. Here, we explore the ability of a tumor-targeted delivery...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Pharm
Hauptverfasser: Svoronos, Alexander A., Bahal, Raman, Pereira, Mohan C., Barrera, Francisco N., Deacon, John C., Bosenberg, Marcus, DiMaio, Daniel, Glazer, Peter M., Engelman, Donald M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191262/
https://ncbi.nlm.nih.gov/pubmed/31855437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00883
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