Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy

Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. H...

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Publicado no:J Clin Invest
Main Authors: Li, Jing, Wang, Weichao, Zhang, Yajia, Cieślik, Marcin, Guo, Jipeng, Tan, Mengyao, Green, Michael D., Wang, Weimin, Lin, Heng, Li, Wei, Wei, Shuang, Zhou, Jiajia, Li, Gaopeng, Jing, Xiaojun, Vatan, Linda, Zhao, Lili, Bitler, Benjamin, Zhang, Rugang, Cho, Kathleen R., Dou, Yali, Kryczek, Ilona, Chan, Timothy A., Huntsman, David, Chinnaiyan, Arul M., Zou, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190935/
https://ncbi.nlm.nih.gov/pubmed/32027624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134402
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