TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis

Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-ma...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Dees, Clara, Pötter, Sebastian, Zhang, Yun, Bergmann, Christina, Zhou, Xiang, Luber, Markus, Wohlfahrt, Thomas, Karouzakis, Emmanuel, Ramming, Andreas, Gelse, Kolja, Yoshimura, Akihiko, Jaenisch, Rudolf, Distler, Oliver, Schett, Georg, Distler, Jörg H.W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190914/
https://ncbi.nlm.nih.gov/pubmed/31990678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122462
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