TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis

Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-ma...

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Pubblicato in:J Clin Invest
Autori principali: Dees, Clara, Pötter, Sebastian, Zhang, Yun, Bergmann, Christina, Zhou, Xiang, Luber, Markus, Wohlfahrt, Thomas, Karouzakis, Emmanuel, Ramming, Andreas, Gelse, Kolja, Yoshimura, Akihiko, Jaenisch, Rudolf, Distler, Oliver, Schett, Georg, Distler, Jörg H.W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190914/
https://ncbi.nlm.nih.gov/pubmed/31990678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122462
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