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The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5
IL-17–producing RORγt(+) γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-...
Gespeichert in:
| Veröffentlicht in: | J Clin Invest |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7190909/ https://ncbi.nlm.nih.gov/pubmed/32281944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131241 |
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