The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5

IL-17–producing RORγt(+) γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Kadekar, Darshana, Agerholm, Rasmus, Rizk, John, Neubauer, Heidi A., Suske, Tobias, Maurer, Barbara, Viñals, Monica Torrellas, Comelli, Elena M., Taibi, Amel, Moriggl, Richard, Bekiaris, Vasileios
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190909/
https://ncbi.nlm.nih.gov/pubmed/32281944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131241
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