Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and survival in conjunction with other core cancer pathways. Nuclear phosphorylated STAT3 and STAT5 regulate cell-type-specific transcription...

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Publicado en:Leukemia
Autores principales: Wingelhofer, Bettina, Neubauer, Heidi A., Valent, Peter, Han, Xiaonan, Constantinescu, Stefan N., Gunning, Patrick T., Müller, Mathias, Moriggl, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087715/
https://ncbi.nlm.nih.gov/pubmed/29728695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0117-x
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