Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and survival in conjunction with other core cancer pathways. Nuclear phosphorylated STAT3 and STAT5 regulate cell-type-specific transcription...

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Vydáno v:Leukemia
Hlavní autoři: Wingelhofer, Bettina, Neubauer, Heidi A., Valent, Peter, Han, Xiaonan, Constantinescu, Stefan N., Gunning, Patrick T., Müller, Mathias, Moriggl, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087715/
https://ncbi.nlm.nih.gov/pubmed/29728695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0117-x
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