LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche. To determine whether cell-intrinsic epigenetic mechanisms contribute to signal-induced transcriptional responses, here we man...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Vinckier, Nicholas K., Patel, Nisha A., Geusz, Ryan J., Wang, Allen, Wang, Jinzhao, Matta, Ileana, Harrington, Austin R., Wortham, Matthew, Wetton, Nichole, Wang, Jianxun, Jhala, Ulupi S., Rosenfeld, Michael G., Benner, Christopher W., Shih, Hung-Ping, Sander, Maike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190832/
https://ncbi.nlm.nih.gov/pubmed/32350257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16017-x
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