טוען...
Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer
The role of dysregulation of mRNA alternative splicing (AS) in the development and progression of solid tumors remains to be defined. Here we describe the first comprehensive AS landscape in the spectrum of human prostate cancer (PCa) evolution. We find that the severity of splicing dysregulation co...
שמור ב:
| הוצא לאור ב: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7190674/ https://ncbi.nlm.nih.gov/pubmed/32350277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15815-7 |
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