Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously expressed regulators of RNA processing. To understand the molecular impact of ALS-causing mutations on neuronal development and disease, we analysed transcriptomes during in vitro differentiation of motor neurons (...

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Publicat a:Nat Commun
Autors principals: Luisier, Raphaelle, Tyzack, Giulia E., Hall, Claire E., Mitchell, Jamie S., Devine, Helen, Taha, Doaa M., Malik, Bilal, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M., Patani, Rickie
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964114/
https://ncbi.nlm.nih.gov/pubmed/29789581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04373-8
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