טוען...
Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
Phosphorylation of MDM2 by ATM upon DNA damage is an important mechanism for deregulating MDM2, thereby leading to p53 activation. ATM phosphorylates multiple residues near the RING domain of MDM2, but the underlying molecular basis for deregulation remains elusive. Here we show that Ser429 phosphor...
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| הוצא לאור ב: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7190642/ https://ncbi.nlm.nih.gov/pubmed/32350255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15783-y |
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