In vitro activity of AST-120 that suppresses indole signaling in Escherichia coli, which attenuates drug tolerance and virulence

AST-120 (Kremezin) is used to treat progressive chronic kidney disease (CKD) by adsorbing uremic toxin precursors produced by gut microbiota, such as indole and phenols. In this study, we propose that AST-120 reduces indole level, consequently suppresses indole effects on induction of drug tolerance...

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Udgivet i:PLoS One
Main Authors: Hirakawa, Hidetada, Uchida, Motoyuki, Kurabayashi, Kumiko, Nishijima, Fuyuhiko, Takita, Ayako, Tomita, Haruyoshi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190153/
https://ncbi.nlm.nih.gov/pubmed/32348373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232461
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