In vitro activity of AST-120 that suppresses indole signaling in Escherichia coli, which attenuates drug tolerance and virulence

AST-120 (Kremezin) is used to treat progressive chronic kidney disease (CKD) by adsorbing uremic toxin precursors produced by gut microbiota, such as indole and phenols. In this study, we propose that AST-120 reduces indole level, consequently suppresses indole effects on induction of drug tolerance...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Hirakawa, Hidetada, Uchida, Motoyuki, Kurabayashi, Kumiko, Nishijima, Fuyuhiko, Takita, Ayako, Tomita, Haruyoshi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190153/
https://ncbi.nlm.nih.gov/pubmed/32348373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232461
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