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Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo
Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene result in late-onset Parkinson’s disease. The incomplete penetrance of LRRK2 mutations in humans and LRRK2 murine models of Parkinson’s disease suggests that the disease may result from a complex interplay of genetic predispositions...
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| Veröffentlicht in: | Brain |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7190032/ https://ncbi.nlm.nih.gov/pubmed/29800472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy077 |
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