Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo

Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene result in late-onset Parkinson’s disease. The incomplete penetrance of LRRK2 mutations in humans and LRRK2 murine models of Parkinson’s disease suggests that the disease may result from a complex interplay of genetic predispositions...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Kozina, Elena, Sadasivan, Shankar, Jiao, Yun, Dou, Yuchen, Ma, Zhijun, Tan, Haiyan, Kodali, Kiran, Shaw, Timothy, Peng, Junmin, Smeyne, Richard J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190032/
https://ncbi.nlm.nih.gov/pubmed/29800472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy077
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