Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines

Histone acetyltransferases (HATs) are important enzymes that transfer acetyl groups onto histones and thereby regulate both gene expression and chromosomal structures. Previous work has shown that the activation of sirtuins, which are histone deacetylases, can extend lifespan. This suggests that inh...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Huang, Boyue, Zhong, Dandan, Zhu, Jie, An, Yongpan, Gao, Miaomiao, Zhu, Shuai, Dang, Weiwei, Wang, Xin, Yang, Baoxue, Xie, Zhengwei
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189995/
https://ncbi.nlm.nih.gov/pubmed/32157780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13129
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