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Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines

Histone acetyltransferases (HATs) are important enzymes that transfer acetyl groups onto histones and thereby regulate both gene expression and chromosomal structures. Previous work has shown that the activation of sirtuins, which are histone deacetylases, can extend lifespan. This suggests that inh...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Huang, Boyue, Zhong, Dandan, Zhu, Jie, An, Yongpan, Gao, Miaomiao, Zhu, Shuai, Dang, Weiwei, Wang, Xin, Yang, Baoxue, Xie, Zhengwei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189995/
https://ncbi.nlm.nih.gov/pubmed/32157780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13129
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