The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

In Saccharomyces cerevisiae, deletion of large ribosomal subunit protein-encoding genes increases the replicative lifespan in a Gcn4-dependent manner. However, how Gcn4, a key transcriptional activator of amino acid biosynthesis genes, increases lifespan, is unknown. Here we show that Gcn4 acts as a...

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Publicado no:Nat Commun
Main Authors: Mittal, Nitish, Guimaraes, Joao C., Gross, Thomas, Schmidt, Alexander, Vina-Vilaseca, Arnau, Nedialkova, Danny D., Aeschimann, Florian, Leidel, Sebastian A., Spang, Anne, Zavolan, Mihaela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587724/
https://ncbi.nlm.nih.gov/pubmed/28878244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00539-y
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