Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease

The transcription factor Nurr1 has been identified to be ectopically induced in the striatum of rodents expressing l-DOPA-induced dyskinesia (LID). In the present study, we sought to characterize Nurr1 as a causative factor in LID expression. We used rAAV2/5 to overexpress Nurr1 or GFP in the parkin...

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Udgivet i:J Neurosci
Main Authors: Sellnow, Rhyomi C., Steece-Collier, Kathy, Altwal, Feras, Sandoval, Ivette M., Kordower, Jeffrey H., Collier, Timothy J., Sortwell, Caryl E., West, Anthony R., Manfredsson, Fredric P.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189759/
https://ncbi.nlm.nih.gov/pubmed/32238479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2936-19.2020
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