JAK2/PD-L1/PD-L2 (9p24.1) Amplifications in Renal Cell Carcinomas with Sarcomatoid Transformation: Implications for Clinical Management

Amplifications of JAK2, PD-L1 and PD-L2 at 9p24.1 lead to constitutive expression of PD-L1. This, coupled with JAK2-activation dependent upregulation of PD-L1 and adaptive/induced expression leads to higher tumor PD-L1 expression and immune evasion. Renal tumors were therefore evaluated for 9p24.1 a...

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Publicado no:Mod Pathol
Main Authors: Gupta, Sounak, Cheville, John C., Jungbluth, Achim A., Zhang, Yanming, Zhang, Lei, Chen, Ying-Bei, Tickoo, Satish K., Fine, Samson W., Gopalan, Anuradha, Al-Ahmadie, Hikmat A., Sirintrapun, Sahussapont J., Blum, Kyle A., Lohse, Christine M., Hakimi, A. Ari, Thompson, R. Houston, Leibovich, Bradley C., Berger, Michael F., Arcila, Maria E., Ross, Dara S., Ladanyi, Marc, Antonescu, Cristina R., Reuter, Victor E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189735/
https://ncbi.nlm.nih.gov/pubmed/30996253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41379-019-0269-x
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