JAK2/PD-L1/PD-L2 (9p24.1) Amplifications in Renal Cell Carcinomas with Sarcomatoid Transformation: Implications for Clinical Management

Amplifications of JAK2, PD-L1 and PD-L2 at 9p24.1 lead to constitutive expression of PD-L1. This, coupled with JAK2-activation dependent upregulation of PD-L1 and adaptive/induced expression leads to higher tumor PD-L1 expression and immune evasion. Renal tumors were therefore evaluated for 9p24.1 a...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Mod Pathol
Autors principals: Gupta, Sounak, Cheville, John C., Jungbluth, Achim A., Zhang, Yanming, Zhang, Lei, Chen, Ying-Bei, Tickoo, Satish K., Fine, Samson W., Gopalan, Anuradha, Al-Ahmadie, Hikmat A., Sirintrapun, Sahussapont J., Blum, Kyle A., Lohse, Christine M., Hakimi, A. Ari, Thompson, R. Houston, Leibovich, Bradley C., Berger, Michael F., Arcila, Maria E., Ross, Dara S., Ladanyi, Marc, Antonescu, Cristina R., Reuter, Victor E.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189735/
https://ncbi.nlm.nih.gov/pubmed/30996253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41379-019-0269-x
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars