ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins

Chemokines are essential for guiding cell migration. Atypical chemokine receptors (ACKRs) contribute to the cell migration process by binding, internalizing and degrading local chemokines, which enables the formation of confined gradients. ACKRs are heptahelical membrane spanning molecules structura...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Matti, Christoph, Salnikov, Angela, Artinger, Marc, D'Agostino, Gianluca, Kindinger, Ilona, Uguccioni, Mariagrazia, Thelen, Marcus, Legler, Daniel F.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188906/
https://ncbi.nlm.nih.gov/pubmed/32391018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00720
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