Risk Variants with Opposing Functional Effects Result in Hypomorphic Expression of TNIP1 and Other Genes within a 3D Chromatin Network

OBJECTIVE: Genetic variants in the region of TNFAIP3 interacting protein 1 (TNIP1) are associated with autoimmune disease and reduced TNIP1 gene expression. This study aimed to define the functional genetic mechanisms driving TNIP1 hypomorphic expression imparted by the SLE-associated TNIP1 H1 risk...

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Pubblicato in:Arthritis Rheumatol
Autori principali: Pasula, Satish, Tessneer, Kandice L., Fu, Yao, Gopalakrishnan, Jaanam, Pelikan, Richard C., Kelly, Jennifer A., Wiley, Graham B., Wiley, Mandi M., Gaffney, Patrick M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188567/
https://ncbi.nlm.nih.gov/pubmed/31804013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41188
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