Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissues

The decision to pursue a monoclonal antibody (mAb) as a therapeutic for disease intervention requires the assessment of many factors, such as target-biology, including the total target burden and its accessibility at the intended site of action, as well as mAb-specific properties like binding affini...

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Publicado en:MAbs
Main Authors: Conner, Kip P., Pastuskovas, Cinthia V., Soto, Marcus, Thomas, Veena A., Wagner, Mylo, Rock, Dan A.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188401/
https://ncbi.nlm.nih.gov/pubmed/32310023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1746520
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