Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity

IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36Ra (formerly IL-1F5) has been reported to antagonize IL-36γ. However, our previous attempts to demonstrate IL-36Ra antag...

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Detalhes bibliográficos
Main Authors: Towne, Jennifer E., Renshaw, Blair R., Douangpanya, Jason, Lipsky, Brian P., Shen, Min, Gabel, Christopher A., Sims, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234937/
https://ncbi.nlm.nih.gov/pubmed/21965679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.267922
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