Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

In the present study, we employed untargeted metabolomics to investigate the synergistic killing mechanism of polymyxin B in combination with an aminoglycoside, amikacin, against a polymyxin-susceptible isolate of Pseudomonas aeruginosa, FADDI-PA111 (MIC = 2 mg/liter for both polymyxin B and amikaci...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Hussein, Maytham, Han, Mei-Ling, Zhu, Yan, Zhou, Qi, Lin, Yu-Wei, Hancock, Robert E. W., Hoyer, Daniel, Creek, Darren J., Li, Jian, Velkov, Tony
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187587/
https://ncbi.nlm.nih.gov/pubmed/31611351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01587-19
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