A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection

Hepatitis B virus (HBV) is a major human pathogen, killing an estimated 887,000 people per year. Therefore, potentially curative therapies are of high importance. Following infection, HBV deposits a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that serves as a transcripti...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Ko, Chunkyu, Bester, Romina, Zhou, Xue, Xu, Zhiheng, Blossey, Christoph, Sacherl, Julia, Vondran, Florian W. R., Gao, Lu, Protzer, Ulrike
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187577/
https://ncbi.nlm.nih.gov/pubmed/31658963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01440-19
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