Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors

Schistosomiasis is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, which affects over 200 million people worldwide and leads to at least 300,000 deaths every year. In this study, initial screening revealed the triazole‐based hydroxamate 2 b (N‐hydroxy‐1‐phenyl‐1H...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Kalinin, Dmitrii V., Jana, Sunit K., Pfafenrot, Maxim, Chakrabarti, Alokta, Melesina, Jelena, Shaik, Tajith B., Lancelot, Julien, Pierce, Raymond J., Sippl, Wolfgang, Romier, Christophe, Jung, Manfred, Holl, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187165/
https://ncbi.nlm.nih.gov/pubmed/31816172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900583
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