Fibrinogen αC‐regions are not directly involved in fibrin polymerization as evidenced by a “Double‐Detroit” recombinant fibrinogen mutant and knobs‐mimic peptides

BACKGROUND: Fibrin polymerization, following fibrinopeptides A and B (FpA, FpB) cleavage, relies on newly exposed α‐ and β‐chains N‐termini (GPR, GHR; A‐, B‐knobs, respectively) engaging preexistent a and b pockets in other fibrin(ogen) molecules' γ‐ and (B)β‐chains C‐terminal regions. A role f...

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Detalles Bibliográficos
Publicado en:J Thromb Haemost
Autores principales: Duval, Cédric, Profumo, Aldo, Aprile, Anna, Salis, Annalisa, Millo, Enrico, Damonte, Gianluca, Gauer, Julia S., Ariëns, Robert A. S., Rocco, Mattia
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
HAEMOSTASIS
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186824/
https://ncbi.nlm.nih.gov/pubmed/31889430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14725
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