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Building better fibrin knob mimics: an investigation of synthetic fibrin knob peptide structures in solution and their dynamic binding with fibrinogen/fibrin holes
Fibrin polymerizes via noncovalent and dynamic association of thrombin-exposed “knobs” with complementary “holes.” Synthetic knob peptides have received significant interest as a means for understanding fibrin assembly mechanisms and inhibiting fibrin polymerization. Nevertheless, the inability to c...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938242/ https://ncbi.nlm.nih.gov/pubmed/20484082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-251801 |
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