Non-disruptive mutation in TP53 DNA-binding domain is a beneficial factor of esophageal squamous cell carcinoma

BACKGROUND: TP53 is frequently altered in esophageal squamous cell carcinoma (ESCC). However, the landscape of TP53 mutation and its effects on patients remain controversial. METHODS: Somatic mutations of TP53 in 161 patients with resectable ESCC were identified by next-generation sequencing (NGS) a...

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Vydáno v:Ann Transl Med
Hlavní autoři: Huang, Minran, Jin, Jiaoyue, Zhang, Fanrong, Wu, Yingxue, Xu, Chenyang, Ying, Lisha, Su, Dan
Médium: Artigo
Jazyk:Inglês
Vydáno: AME Publishing Company 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186752/
https://ncbi.nlm.nih.gov/pubmed/32355760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2020.02.142
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