PRIMA‐1 induces p53‐mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation

TP53 is associated with the resistance of cytotoxic treatment and patient prognosis, and the mutation rate of TP53 in esophageal squamous cell carcinoma (ESCC) is extraordinarily high, at over 90%. PRIMA‐1 (p53 re‐activation and induction of massive apoptosis) has recently been reported to restore t...

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Dades bibliogràfiques
Publicat a:Cancer Sci
Autors principals: Furukawa, Haruna, Makino, Tomoki, Yamasaki, Makoto, Tanaka, Koji, Miyazaki, Yasuhiro, Takahashi, Tsuyoshi, Kurokawa, Yukinori, Nakajima, Kiyokazu, Takiguchi, Shuji, Mori, Masaki, Doki, Yuichiro
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797815/
https://ncbi.nlm.nih.gov/pubmed/29168598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13454
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