PRIMA‐1 induces p53‐mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation

TP53 is associated with the resistance of cytotoxic treatment and patient prognosis, and the mutation rate of TP53 in esophageal squamous cell carcinoma (ESCC) is extraordinarily high, at over 90%. PRIMA‐1 (p53 re‐activation and induction of massive apoptosis) has recently been reported to restore t...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Furukawa, Haruna, Makino, Tomoki, Yamasaki, Makoto, Tanaka, Koji, Miyazaki, Yasuhiro, Takahashi, Tsuyoshi, Kurokawa, Yukinori, Nakajima, Kiyokazu, Takiguchi, Shuji, Mori, Masaki, Doki, Yuichiro
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797815/
https://ncbi.nlm.nih.gov/pubmed/29168598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13454
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