An effective CTL peptide vaccine for Ebola Zaire Based on Survivors’ CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design

The 2013–2016 West Africa EBOV epidemic was the biggest EBOV outbreak to date. An analysis of virus-specific CD8+ T-cell immunity in 30 survivors showed that 26 of those individuals had a CD8+ response to at least one EBOV protein. The dominant response (25/26 subjects) was specific to the EBOV nucl...

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Publicado en:Vaccine
Main Authors: Herst, C.V., Burkholz, S., Sidney, J., Sette, A., Harris, P.E., Massey, S., Brasel, T., Cunha-Neto, E., Rosa, D.S., Chao, W.C.H., Carback, R., Hodge, T., Wang, L., Ciotlos, S., Lloyd, P., Rubsamen, R.
Formato: Artigo
Idioma:Inglês
Publicado: The Author(s). Published by Elsevier Ltd. 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186210/
https://ncbi.nlm.nih.gov/pubmed/32418793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2020.04.034
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