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X-ray structures of catalytic intermediates of cytochrome c oxidase provide insights into its O(2) activation and unidirectional proton-pump mechanisms

Cytochrome c oxidase (CcO) reduces O(2) to water, coupled with a proton-pumping process. The structure of the O(2)-reduction site of CcO contains two reducing equivalents, Fe(a)(3)(2+) and Cu(B)(1+), and suggests that a peroxide-bound state (Fe(a)(3)(3+)–O(−)–O(−)–Cu(B)(2+)) rather than an O(2)-boun...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shimada, Atsuhiro, Etoh, Yuki, Kitoh-Fujisawa, Rika, Sasaki, Ai, Shinzawa-Itoh, Kyoko, Hiromoto, Takeshi, Yamashita, Eiki, Muramoto, Kazumasa, Tsukihara, Tomitake, Yoshikawa, Shinya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186171/
https://ncbi.nlm.nih.gov/pubmed/32165497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009596
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