ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we uncover a novel mechanism of ADAM10- and ADAM17-mediated resistan...

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Vydáno v:Oncoimmunology
Hlavní autoři: Orme, Jacob J., Jazieh, Khalid A., Xie, Tiancheng, Harrington, Susan, Liu, Xin, Ball, Matthew, Madden, Benjamin, Charlesworth, M. Cristine, Azam, Tariq U., Lucien, Fabrice, Wootla, Bharath, Li, Yanli, Villasboas, Jose Caetano, Mansfield, Aaron S., Dronca, Roxana S., Dong, Haidong
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185206/
https://ncbi.nlm.nih.gov/pubmed/32363112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1744980
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