ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we uncover a novel mechanism of ADAM10- and ADAM17-mediated resistan...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Orme, Jacob J., Jazieh, Khalid A., Xie, Tiancheng, Harrington, Susan, Liu, Xin, Ball, Matthew, Madden, Benjamin, Charlesworth, M. Cristine, Azam, Tariq U., Lucien, Fabrice, Wootla, Bharath, Li, Yanli, Villasboas, Jose Caetano, Mansfield, Aaron S., Dronca, Roxana S., Dong, Haidong
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185206/
https://ncbi.nlm.nih.gov/pubmed/32363112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1744980
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