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Supraphysiological protection from replication stress does not extend mammalian lifespan
Replication Stress (RS) is a type of DNA damage generated at the replication fork, characterized by single-stranded DNA (ssDNA) accumulation, and which can be caused by a variety of factors. Previous studies have reported elevated RS levels in aged cells. In addition, mouse models with a deficient R...
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| Publicado no: | Aging (Albany NY) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7185120/ https://ncbi.nlm.nih.gov/pubmed/32253367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103039 |
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