RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

The availability of nucleotides has a direct impact on transcription. Inhibition of dihydroorate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels. Leflunomide abrogates effective transcription elongation of genes required for neural crest development and...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Santoriello, Cristina, Sporrij, Audrey, Yang, Song, Flynn, Ryan A., Henriques, Telmo, Dorjsuren, Bilguujin, Greig, Eugenia Custo, McCall, Wyatt, Stanhope, Meredith E., Fazio, Maurizio, Superdock, Michael, Lichtig, Asher, Adatto, Isaac, Abraham, Brian J., Kalocsay, Marian, Jurynec, Michael, Zhou, Yi, Adelman, Karen, Calo, Eliezer, Zon, Leonard I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185069/
https://ncbi.nlm.nih.gov/pubmed/32231306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0493-0
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