RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

The availability of nucleotides has a direct impact on transcription. Inhibition of dihydroorate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels. Leflunomide abrogates effective transcription elongation of genes required for neural crest development and...

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Publié dans:Nat Cell Biol
Auteurs principaux: Santoriello, Cristina, Sporrij, Audrey, Yang, Song, Flynn, Ryan A., Henriques, Telmo, Dorjsuren, Bilguujin, Greig, Eugenia Custo, McCall, Wyatt, Stanhope, Meredith E., Fazio, Maurizio, Superdock, Michael, Lichtig, Asher, Adatto, Isaac, Abraham, Brian J., Kalocsay, Marian, Jurynec, Michael, Zhou, Yi, Adelman, Karen, Calo, Eliezer, Zon, Leonard I.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185069/
https://ncbi.nlm.nih.gov/pubmed/32231306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0493-0
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