RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

The availability of nucleotides has a direct impact on transcription. Inhibition of dihydroorate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels. Leflunomide abrogates effective transcription elongation of genes required for neural crest development and...

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Опубликовано в: :Nat Cell Biol
Главные авторы: Santoriello, Cristina, Sporrij, Audrey, Yang, Song, Flynn, Ryan A., Henriques, Telmo, Dorjsuren, Bilguujin, Greig, Eugenia Custo, McCall, Wyatt, Stanhope, Meredith E., Fazio, Maurizio, Superdock, Michael, Lichtig, Asher, Adatto, Isaac, Abraham, Brian J., Kalocsay, Marian, Jurynec, Michael, Zhou, Yi, Adelman, Karen, Calo, Eliezer, Zon, Leonard I.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185069/
https://ncbi.nlm.nih.gov/pubmed/32231306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0493-0
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