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Local Conformational Dynamics Regulating Transport Properties of a Cl(−)/H(+) Antiporter
ClC-ec1 is a Cl(−)/H(+) antiporter that exchanges Cl(−) and H(+) ions across the membrane. Experiments have demonstrated that several mutations, including I109F, decrease the Cl(−) and H(+) transport rates by an order of magnitude. Using reactive molecular dynamics simulations of explicit proton tra...
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| Publicado no: | J Comput Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7184886/ https://ncbi.nlm.nih.gov/pubmed/31633205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.26093 |
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