Autophagy mediates hepatic GRK2 degradation to facilitate glucagon-induced metabolic adaptation to fasting

The liver plays a key role during fasting to maintain energy homeostasis and euglycaemia via metabolic processes mainly orchestrated by the insulin/glucagon ratio. We report here that fasting or calorie restriction protocols in C57BL6/J mice promote a marked decrease in the hepatic protein levels of...

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Publicat a:FASEB J
Autors principals: Cruces-Sande, Marta, Arcones, Alba C., Vila-Bedmar, Rocío, Val-Blasco, Almudena, Sharabi, Kfir, Díaz-Rodríguez, Daniel, Puigserver, Pere, Mayor, Federico, Murga, Cristina
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184883/
https://ncbi.nlm.nih.gov/pubmed/31914606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901444R
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