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Engineering a human IgG2 antibody stable at low pH
IgG2 subclass antibodies have unique properties that include low effector function and a rigid hinge region. Although some IgG2 subclasses have been clinically tested and approved for therapeutic use, they have a higher propensity than IgG1 for aggregation, which can curtail or abolish their biologi...
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| Vydáno v: | Protein Sci |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley & Sons, Inc.
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7184777/ https://ncbi.nlm.nih.gov/pubmed/32142185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3852 |
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