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A stable engineered human IgG3 antibody with decreased aggregation during antibody expression and low pH stress
Human IgG comprises four subclasses with different biological functions. The IgG3 subclass has a unique character, exhibiting high effector function and Fab arm flexibility. However, it is not used as a therapeutic drug owing to an enhanced susceptibility to proteolysis. Antibody aggregation control...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6459999/ https://ncbi.nlm.nih.gov/pubmed/30834577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3598 |
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