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Trapping a Folding Intermediate of the R-Helix: Stabilization of the π-Helix

We report the design, synthesis, and characterization of a short peptide trapped in a π-helix configuration. This high-energy conformation was nucleated by a preorganized π-turn, which was obtained by replacing an N-terminal intramolecular main chain i and i + 5 hydrogen bond with a carbon-carbon bo...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Chapman, Ross, Kulp, John L., Patgiri, Anupam, Kallenbach, Neville R., Bracken, Clay, Arora, Paramjit S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183248/
https://ncbi.nlm.nih.gov/pubmed/18335996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800136m
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