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A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination

Current multiple sclerosis (MS) medications are mainly immunomodulatory, having little or no effect on neuroregeneration of damaged central nervous system (CNS) tissue; they are thus primarily effective at the acute stage of disease, but much less so at the chronic stage. An MS therapy that has both...

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhang, Yuan, Li, Xing, Ciric, Bogoljub, Curtis, Mark T., Chen, Wan-Jun, Rostami, Abdolmohamad, Zhang, Guang-Xian
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183235/
https://ncbi.nlm.nih.gov/pubmed/32253301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000208117
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