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A masked initiation region in retinoblastoma protein regulates its proteasomal degradation

Retinoblastoma protein (Rb) is a tumor suppressor that binds and represses E2F transcription factors. In cervical cancer cells, human papilloma virus (HPV) protein E7 binds to Rb, releasing it from E2F to promote cell cycle progression, and inducing ubiquitination of Rb. E7-mediated proteasomal degr...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Tomita, Takuya, Huibregtse, Jon M., Matouschek, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181824/
https://ncbi.nlm.nih.gov/pubmed/32332747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16003-3
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