Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models

The development of immune checkpoint inhibitors represents a major breakthrough in cancer therapy. Nevertheless, a substantial number of patients fail to respond to checkpoint pathway blockade. Evidence for WNT/β-catenin signaling-mediated immune evasion is found in a subset of cancers including mel...

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Publicat a:Commun Biol
Autors principals: Waaler, Jo, Mygland, Line, Tveita, Anders, Strand, Martin Frank, Solberg, Nina Therese, Olsen, Petter Angell, Aizenshtadt, Aleksandra, Fauskanger, Marte, Lund, Kaja, Brinch, Shoshy Alam, Lycke, Max, Dybing, Elisabeth, Nygaard, Vegard, Bøe, Sigurd Læines, Heintz, Karen-Marie, Hovig, Eivind, Hammarström, Clara, Corthay, Alexandre, Krauss, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181813/
https://ncbi.nlm.nih.gov/pubmed/32332858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0916-2
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