HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to globally map the mRNA targets of the RBP MSI2 in mammalian adult normal and malign...

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Udgivet i:Nat Commun
Main Authors: Nguyen, Diu T. T., Lu, Yuheng, Chu, Eren L., Yang, Xuejing, Park, Sun-Mi, Choo, Zi-Ning, Chin, Christopher R., Prieto, Camila, Schurer, Alexandra, Barin, Ersilia, Savino, Angela M., Gourkanti, Saroj, Patel, Payal, Vu, Ly P., Leslie, Christina S., Kharas, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181745/
https://ncbi.nlm.nih.gov/pubmed/32332729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15814-8
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