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Molecular basis for assembly of the shieldin complex and its implications for NHEJ
Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions as a bridge linking 53BP1-RIF1 and single-strand DNA to suppress the DNA termini nucleolytic resection during non-homologous end joining (NHEJ). However, the mechanism of shieldin assembly remains unclear. Here we present the crystal struct...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7181697/ https://ncbi.nlm.nih.gov/pubmed/32332881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15879-5 |
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